Our research group's focal goal is to develop novel strategies to efficiently access chemical entities with lower ecological and economic impacts. To achieve this aim, we will employ earth-abundant transition metal-catalysis to enable chemical transformations via C-H activation, dearomative difunctionalization, and photocatalytic radical cross-coupling processes. Transition metal catalysis is central to enhance organic synthesis's sustainability by allowing shorter, more selective, less energy demanding synthetic routes, meeting the green chemistry criteria.
«Palladium-catalyzed oxidation of β-C(sp3)-H bond of primary alkylamines through a rare four-membered palladacycle intermediate »
B. Su, Y. Qiu, A. Bunescu, M. Ernst, S. Zuend and J. F. Hartwig, J. Am. Chem. Soc. 2020, 142, 7912–7919.
«Traceless Silylation of β‑C(sp3)−H Bonds of Alcohols via Perfluorinated Acetals»
A. Bunescu, T. W. Butcher and J. F. Hartwig, J. Am. Chem. Soc. 2018, 140, 1502-1507.