The Bunescu Research Group University of Bonn

Our approach
 

Our research group's focal goal is to develop novel strategies to efficiently access chemical entities with lower ecological and economic impacts. To achieve this aim, we will employ earth-abundant transition metal-catalysis to enable chemical transformations via C-H activation, dearomative difunctionalization, and photocatalytic radical cross-coupling processes. Transition metal catalysis is central to enhance organic synthesis's sustainability by allowing shorter, more selective, less energy demanding synthetic routes, meeting the green chemistry criteria.
 

 
Research Interests
  • Non-directed C-H functionalization
     

  • Dearomative difunctionalization
     

  • Photocatalytic intramolecular ET

 
Publications

«Multicomponent alkene azido-arylation via anion-mediated dual catalysis»

A. Bunescu, Y. Abdelhamid, and M.J. Gaunt, Nature 2021, 598,  597–603.

DOI : 10.1038/s41586-021-03980-8

 

«Palladium-catalyzed oxidation of β-C(sp3)-H bond of primary alkylamines through a rare four-membered palladacycle intermediate »

B. Su, Y. Qiu, A. Bunescu, M. Ernst, S. Zuend and J. F. Hartwig, J. Am. Chem. Soc. 2020, 142, 7912–7919.

DOI: 10.1021/jacs.0c01629

 

 «Traceless Silylation of β‑C(sp3)−H Bonds of Alcohols via Perfluorinated Acetals»

A. Bunescu, T. W. Butcher and J. F. Hartwig, J. Am. Chem. Soc2018, 140, 1502-1507.

DOI: 10.1021/jacs.7b12150